Research Articles
Navigating Zero-Inflation and Overdispersion: A Statistical Guide for Robust Microbiome Data Analysis
Microbiome data from high-throughput sequencing are characterized by zero-inflation and overdispersion, posing significant challenges for robust statistical analysis in biomedical and clinical research.
Microbiome Data Normalization: A Comprehensive Guide to Rarefaction, Filtering, and Advanced Methods for Robust Analysis
This article provides a comprehensive guide to normalization and filtering for 16S rRNA and shotgun metagenomic data, tailored for researchers and drug development professionals.
A Researcher's Guide to Controlling Contamination in Low Microbial Biomass Microbiome Studies
This article provides a comprehensive framework for researchers and drug development professionals to address the critical challenge of contamination in low microbial biomass microbiome studies.
From Bench to Bedside: The Clinical Translation of the Human Microbiome in Diagnostics and Therapeutics
This article synthesizes the rapid evolution of microbiome science from a research field to a cornerstone of clinical innovation.
Microbiome Network Inference: A Comprehensive Guide to Methods, Applications, and Validation
This article provides a comprehensive overview of the rapidly evolving field of microbiome network inference, a key exploratory technique for understanding complex microbial interactions and their implications for human health...
Longitudinal Microbiome Data Analysis: A Comprehensive Guide to Time-Series Methods for Biomedical Research
This article provides a comprehensive overview of methodological considerations and computational tools for analyzing longitudinal microbiome data.
Microbiome Differential Abundance Testing: A Comprehensive Guide for Robust Biomarker Discovery
Differential abundance analysis (DAA) is a cornerstone statistical task in microbiome research, essential for identifying microbial biomarkers linked to health and disease.
Multi-Omics Integration of the Microbiome and Metabolome: Methods, Applications, and Biomarker Discovery in Disease
This article provides a comprehensive overview for researchers and drug development professionals on the integration of microbiome multi-omics data, with a special focus on metabolomics.
Navigating the Multiple Comparisons Problem in Microbiome Analysis: A Practical Guide for Robust Statistical Inference
This article provides a comprehensive framework for researchers and drug development professionals to address the critical challenge of multiple comparisons correction in microbiome statistical analysis.
Shotgun Metagenomic Sequencing: A Comprehensive Guide to Microbiome Functional Analysis for Biomedical Research
This article provides a comprehensive overview of shotgun metagenomic sequencing for microbiome functional analysis, tailored for researchers, scientists, and drug development professionals.