Research Articles
Microbiome Network Inference: A Comprehensive Guide to Methods, Applications, and Validation
This article provides a comprehensive overview of the rapidly evolving field of microbiome network inference, a key exploratory technique for understanding complex microbial interactions and their implications for human health...
Longitudinal Microbiome Data Analysis: A Comprehensive Guide to Time-Series Methods for Biomedical Research
This article provides a comprehensive overview of methodological considerations and computational tools for analyzing longitudinal microbiome data.
Microbiome Differential Abundance Testing: A Comprehensive Guide for Robust Biomarker Discovery
Differential abundance analysis (DAA) is a cornerstone statistical task in microbiome research, essential for identifying microbial biomarkers linked to health and disease.
Multi-Omics Integration of the Microbiome and Metabolome: Methods, Applications, and Biomarker Discovery in Disease
This article provides a comprehensive overview for researchers and drug development professionals on the integration of microbiome multi-omics data, with a special focus on metabolomics.
Navigating the Multiple Comparisons Problem in Microbiome Analysis: A Practical Guide for Robust Statistical Inference
This article provides a comprehensive framework for researchers and drug development professionals to address the critical challenge of multiple comparisons correction in microbiome statistical analysis.
Shotgun Metagenomic Sequencing: A Comprehensive Guide to Microbiome Functional Analysis for Biomedical Research
This article provides a comprehensive overview of shotgun metagenomic sequencing for microbiome functional analysis, tailored for researchers, scientists, and drug development professionals.
A Comprehensive Guide to 16S rRNA Gene Sequencing for Microbiome Analysis: From Foundational Principles to Advanced Applications in Biomedical Research
This article provides a comprehensive protocol and critical analysis of 16S rRNA gene sequencing for microbiome analysis, tailored for researchers, scientists, and drug development professionals.
Navigating the Chaos: A Research-Focused Guide to Individual Variability in the Core Stool Microbiome
This article provides a comprehensive analysis of individual variability in the human gut microbiome for researchers and drug development professionals.
Beyond Sterility: Investigating the Microbiome in Traditional Sterile Human Sites and Its Implications for Disease and Therapeutics
This article examines the paradigm-shifting controversy surrounding the existence of microbiomes in human sites traditionally considered sterile, such as the placenta, blood, and brain.
OTUs vs. ASVs: A Comprehensive Guide for Metagenomic Analysis in Biomedical Research
This article provides a comprehensive analysis of Operational Taxonomic Units (OTUs) and Amplicon Sequence Variants (ASVs) for researchers and professionals in drug development and clinical research.