Research Articles
16S rRNA vs Shotgun Metagenomics: A Strategic Guide for Biomedical Researchers
This article provides a comprehensive comparison of 16S rRNA gene sequencing and shotgun metagenomics for researchers and drug development professionals.
Controlling Confounding Factors in Microbiome Research: A Strategic Guide for Managing Age, Diet, and Antibiotic Variables
This article provides a comprehensive framework for researchers and drug development professionals to identify, understand, and control for major confounding factors in human microbiome studies.
Controlling False Discoveries in Microbiome Studies: A Comprehensive Guide to FDR Methods for Robust Differential Abundance Analysis
This article provides a comprehensive guide to false discovery rate (FDR) control methods in microbiome differential abundance analysis for researchers and drug development professionals.
Validating Microbiome Biomarkers for Clinical Diagnostics: From Cohort Studies to Clinical Implementation
This comprehensive review examines the critical pathway for validating microbiome-based diagnostic biomarkers across diverse disease contexts.
Validating Microbiome Analysis: From Consensus Standards to Clinical Translation
This article synthesizes current international consensus and best practices for validating microbiome analysis approaches, targeting researchers and drug development professionals.
Bridging the Translational Gap: Establishing Causality Between Animal Models and Human Studies in Microbiome Research
This article provides a comprehensive analysis for researchers and drug development professionals on the critical relationship between animal model findings and human studies in microbiome research.
Designing Robust Microbiome Studies: A Comprehensive Guide to Cross-Sectional and Longitudinal Study Validation
This article provides a comprehensive framework for designing and validating cross-sectional and longitudinal microbiome studies, specifically tailored for researchers, scientists, and drug development professionals.
Microbiome Taxonomic Databases Compared: A Practical Guide to Greengenes, SILVA, and RDP for Researchers
This article provides a comprehensive comparison of the major taxonomic databases—Greengenes, SILVA, and RDP—used in microbiome research.
Microbiome Pipeline Reproducibility: A Comprehensive Comparison of DADA2, QIIME2, and MOTHUR for Robust Biomedical Research
Reproducibility in microbiome bioinformatics is paramount for translating microbial signatures into clinical and pharmaceutical applications.
Microbiome Differential Abundance Analysis: A Comprehensive Benchmarking Review for Robust Biomarker Discovery
Differential abundance (DA) analysis is a cornerstone of microbiome research, essential for identifying microbial biomarkers associated with health and disease.